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BENOQUIN

The original monobenzone cream

mONOBENZONE CREAM U.S.P. 20%W/w

  • Benoquin is original monobenzone  cream USP 20% w/w
  • Monobenzone is used as a topical drug for medical depigmentation. It works by increasing the elimination of melanin (pigment molecules) from skin cells. It is a colorless solid that is classified as the monobenzyl ether of hydroquinone. Monobenzone is soluble in alcohol, benzene, and diethyl ether, and practically insoluble in water.
  • Formula: Benoquin cream is 20% purified monobenzyl ether of hydroquinone (MONOBENZONE CREAM USP) in a special base.

Role of Benoquin in the treatment of Vitiligo & Hyperpigmentation

Vitiligo

 

  • Vitiligo is a disease that causes the loss of skin color in blotches. It is one of the most common dermatological disorders, appearing as one or more white macules or patches on the body.
  • The extent and rate of color loss from vitiligo is unpredictable. It can affect the skin on any part of your body. It may also affect the hair and the inside of the mouth.
  • Normally, the color of hair and skin is determined by melanin. Vitiligo occurs when the cells that produce melanin die or stop functioning. Vitiligo affects people of all skin types, but it may be more noticeable in people with darker skin. The condition is not life-threatening or contagious. Vitiligo can increase stress and decrease confidence.
  • The undesirable aesthetic properties of vitiligo, especially facial, may result in significant negative psychosocial effects, particularly a rate of depression twice that of the general population. 
  • While there is no cure, there are several treatment options, which notably bring about depigmentation in severe cases.

Symptoms of Vitiligo 

  • The main sign of vitiligo is patchy loss of skin color. Usually, the discoloration first shows on sun-exposed areas, such as the hands, feet, arms, face and lips. Early signs of Vitiligo include the following:
  • Patchy loss of skin color.
  • Premature whitening or graying of the hair on your scalp, eyelashes, eyebrows or beard.
  • Loss of color in the tissues that line the inside of your mouth and nose (mucous membranes).
  • Loss of or change in color of the inner layer of the eyeball (retina).
  • Depending on the type of vitiligo you have, the discolored patches may cover different areas of the body.
  • Many parts of the body: With this most common type, called generalized vitiligo, the discolored patches often progress similarly on corresponding body parts (symmetrically).
  • Only one side or part of the body: This type, called segmental vitiligo, tends to occur at a younger age, progress for a year or two, then stops.
  • One or only a few areas of the body: This type is called localized (focal) vitiligo.

How does Benoquin help in Vitiligo?

  • The use of Monobenzone as a depigmenting agent dates back to the 1930's, where its effectiveness made it a very popular treatment for a wide range of pigment disorders. 
  • Monobenzone is the most potent depigmenting agent. timely and aggressive treatment with monobenzone is warranted, demonstrating excellent clinical response, which results in a significant increase in the quality of life in patients with severe vitiligo.
  • There is no cure for vitiligo. Current treatment for vitiligo attempts to either increase or decrease pigmentation in order to achieve cosmetically pleasing results and increase the patient's self-esteem.
  • Monobenzone (monobenzyl ether of hydroquinone, MBEH) is usually the treatment of choice of depigmentation therapy for severe cases of vitiligo, and MBEH is usually used in concentrations of 20 to 40 percent to achieve the desired permanent depigmentation.
  • Despite these negative side effects, its potential cosmetic and psychosocial benefits are significant and should always be taken into consideration when treating these patients.

Hyperpigmentation

 

  • Hyperpigmentation is a common condition in which patches of skin become darker in color than the normal surrounding skin. This darkening occurs when an excess of melanin, the brown pigment that produces normal skin color, forms deposits in the skin. 
  • Hyperpigmentation appears as darkened patches or spots on the skin that make skin look uneven. The spots are known as age spots or sun spots and hyperpigmentation is also at the heart of skin conditions such as melasma and post-inflammatory hyperpigmentation.
  • People with dark skin are normally more affected by hyperpigmentation marks than those with a lighter skin tone, as skin pigmentation is stronger in dark skin.
  •  Hyperpigmentation can affect the skin color of people of any race. It is usually harmless.